Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development.

Hodgkin disease (HD) is characterized by a small number of putative malignant cells [Hodgkin and Reed-Sternberg (HRS) cells] among a background of lymphocytes and histiocytes. The lineage of HRS cells is still elusive and a clonal origin of these rare cells has not formally been demonstrated. We iso...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Küppers, R, Rajewsky, K, Zhao, M, Simons, G, Laumann, R, Fischer, R, Hansmann, M L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45146/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7971992/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.23.10962
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