RNA interference-mediated silencing of the polo-like kinase 1 gene enhances chemosensitivity to gemcitabine in pancreatic adenocarcinoma cells

Gemcitabine is the first-line chemotherapeutic agent for advanced adenocarcinoma of the pancreas; however, chemoresistance to gemcitabine remains a major cause of failure for the clinical treatment of this disease. Polo-like kinase 1 (Plk-1) is highly expressed in pancreatic cancer cell lines and pa...

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Veröffentlicht in:J Cell Mol Med
Hauptverfasser: Yu, C, Zhang, X, Sun, G, Guo, X, Li, H, You, Y, Jacobs, J L, Gardner, K, Yuan, D, Xu, Z, Du, Q, Dai, C, Qian, Z, Jiang, K, Zhu, Y, Li, Q Q, Miao, Y
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4514112/
https://ncbi.nlm.nih.gov/pubmed/18266952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00257.x
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