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Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain.

The CD45 transmembrane protein-tyrosine phosphatase (PTPase, EC 3.1.3.48) plays an essential role in T-cell activation by activating the Lck and/or Fyn protein-tyrosine kinases. However, numerous experiments have indicated that CD45 may have both stimulatory and inhibitory roles in T-cell activation...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Furukawa, T, Itoh, M, Krueger, N X, Streuli, M, Saito, H
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45139/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7526385/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.23.10928
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