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The poor homology stringency in the heteroduplex allows strand exchange to incorporate desirable mismatches without sacrificing recognition in vivo

RecA family proteins are responsible for homology search and strand exchange. In bacteria, homology search begins after RecA binds an initiating single-stranded DNA (ssDNA) in the primary DNA-binding site, forming the presynaptic filament. Once the filament is formed, it interrogates double-stranded...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Danilowicz, Claudia, Yang, Darren, Kelley, Craig, Prévost, Chantal, Prentiss, Mara
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513875/
https://ncbi.nlm.nih.gov/pubmed/26089391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv610
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