Natural variability of minimotifs in 1092 people indicates that minimotifs are targets of evolution

Since the function of a short contiguous peptide minimotif can be introduced or eliminated by a single point mutation, these functional elements may be a source of human variation and a target of selection. We analyzed the variability of ∼300 000 minimotifs in 1092 human genomes from the 1000 Genome...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Lyon, Kenneth F., Strong, Christy L., Schooler, Steve G., Young, Richard J., Roy, Nervik, Ozar, Brittany, Bachmeier, Mark, Rajasekaran, Sanguthevar, Schiller, Martin R.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Genomics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513861/
https://ncbi.nlm.nih.gov/pubmed/26068475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv580
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