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High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression

BACKGROUND: Elevated basal, ligand-independent, Wnt signaling in some canine breast cancer cells is not caused by classical mutations in APC, β-Catenin or GSK3β but, at least partially, by enhanced LEF1 expression. We examined the expression and function of EGFR/HER-regulated pathways on the ligand-...

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Foilsithe in:BMC Cancer
Main Authors: Timmermans-Sprang, Elpetra P. M., Gracanin, Ana, Mol, Jan A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513708/
https://ncbi.nlm.nih.gov/pubmed/26205886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1544-y
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