Ovarian Hormone Fluctuation, Neurosteroids and HPA Axis Dysregulation in Perimenopausal Depression: A Novel Heuristic Model

OBJECTIVE: In this conceptual review, we propose a novel mechanistic candidate in the etiology of depression with onset in the menopause transition (a.k.a. perimenopausal depression) involving alterations in stress-responsive pathways, induced by ovarian hormone fluctuation. METHODS: The relevant li...

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Udgivet i:Am J Psychiatry
Main Authors: Gordon, Jennifer L., Girdler, Susan S., Meltzer-Brody, Samantha E., Stika, Catherine S., Thurston, Rebecca C., Clark, Crystal T., Prairie, Beth A., Moses-Kolko, Eydie, Joffe, Hadine, Wisner, Katherine L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513660/
https://ncbi.nlm.nih.gov/pubmed/25585035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1176/appi.ajp.2014.14070918
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