Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation

Chromosome segregation in mitosis is orchestrated by the dynamic interactions between the kinetochore and spindle microtubules. The microtubule depolymerase mitotic centromere-associated kinesin (MCAK) is a key regulator for an accurate kinetochore-microtubule attachment. However, the regulatory mec...

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Publicat a:Sci Rep
Autors principals: Shao, Hengyi, Huang, Yuejia, Zhang, Liangyu, Yuan, Kai, Chu, Youjun, Dou, Zhen, Jin, Changjiang, Garcia-Barrio, Minerva, Liu, Xing, Yao, Xuebiao
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513279/
https://ncbi.nlm.nih.gov/pubmed/26206521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12204
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