Platelet geometry sensing spatially regulates α-granule secretion to enable matrix self-deposition

Although the biology of platelet adhesion on subendothelial matrix after vascular injury is well characterized, how the matrix biophysical properties affect platelet physiology is unknown. Here we demonstrate that geometric orientation of the matrix itself regulates platelet α-granule secretion, a k...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Sakurai, Yumiko, Fitch-Tewfik, Jennifer L., Qiu, Yongzhi, Ahn, Byungwook, Myers, David R., Tran, Reginald, Fay, Meredith E., Ding, Lingmei, Spearman, Paul W., Michelson, Alan D., Flaumenhaft, Robert, Lam, Wilbur A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2015
Konular:
Platelets and Thrombopoiesis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513253/
https://ncbi.nlm.nih.gov/pubmed/25964667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-11-607614
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