Platelet geometry sensing spatially regulates α-granule secretion to enable matrix self-deposition

Although the biology of platelet adhesion on subendothelial matrix after vascular injury is well characterized, how the matrix biophysical properties affect platelet physiology is unknown. Here we demonstrate that geometric orientation of the matrix itself regulates platelet α-granule secretion, a k...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Blood
Main Authors: Sakurai, Yumiko, Fitch-Tewfik, Jennifer L., Qiu, Yongzhi, Ahn, Byungwook, Myers, David R., Tran, Reginald, Fay, Meredith E., Ding, Lingmei, Spearman, Paul W., Michelson, Alan D., Flaumenhaft, Robert, Lam, Wilbur A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513253/
https://ncbi.nlm.nih.gov/pubmed/25964667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-11-607614
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados