Methyl CpG Binding Protein 2 Gene Disruption Augments Tonic Currents of γ-Aminobutyric Acid Receptors in Locus Coeruleus Neurons: IMPACT ON NEURONAL EXCITABILITY AND BREATHING

People with Rett syndrome and mouse models show autonomic dysfunction involving the brain stem locus coeruleus (LC). Neurons in the LC of Mecp2-null mice are overly excited, likely resulting from a defect in neuronal intrinsic membrane properties and a deficiency in GABA synaptic inhibition. In addi...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Zhong, Weiwei, Cui, Ningren, Jin, Xin, Oginsky, Max F., Wu, Yang, Zhang, Shuang, Bondy, Brian, Johnson, Christopher M., Jiang, Chun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Neurobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513101/
https://ncbi.nlm.nih.gov/pubmed/25979331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.650465
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