Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase

BACKGROUND: Impaired coagulation contributes to the morbidity and mortality associated with septic shock. Whether abnormal platelet contraction adds to the bleeding tendency is unknown. Platelets contract when Ca(2+)-dependent myosin light chain kinase (MLCK) phosphorylates Ser19 of myosin light cha...

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Udgivet i:Intensive Care Med Exp
Main Authors: Reddi, Benjamin AJ, Iannella, Samantha M, O’Connor, Stephanie N, Deane, Adam M, Willoughby, Scott R, Wilson, David P
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4512995/
https://ncbi.nlm.nih.gov/pubmed/26215804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40635-014-0037-7
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