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Anti-VEGF Therapy Revived by c-Met Inhibition, But Is c-Met the Answer?
A new study by Sennino and colleagues demonstrates that selective VEGF inhibition via the use of an anti-VEGF antibody is sufficient to increase invasion and metastasis in a c-Met–dependent manner. Anti-VEGF therapy induced tumor hypoxia, hypoxia-inducible factor 1α, and c-Met activation in the RIP-...
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| Published in: | Cancer Discov |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4512948/ https://ncbi.nlm.nih.gov/pubmed/22585992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-12-0037 |
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