Two Distinct Hepatitis C Virus Genotype 1a Clades Have Different Geographical Distribution and Association With Natural Resistance to NS3 Protease Inhibitors

Background. Hepatitis C virus (HCV) genotype 1 is the most prevalent worldwide. Subtype 1a, compared with 1b, shows lower response rates and higher propensity to select for drug resistance to NS3 and selected NS5A and nonnucleoside NS5B inhibitors. Two distinct clades of subtype 1a have been describ...

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Bibliografski detalji
Izdano u:Open Forum Infect Dis
Glavni autori: De Luca, Andrea, Di Giambenedetto, Simona, Lo Presti, Alessandra, Sierra, Saleta, Prosperi, Mattia, Cella, Eleonora, Giovanetti, Marta, Torti, Carlo, Caudai, Cinzia, Vicenti, Ilaria, Saladini, Francesco, Almi, Paolo, Grima, Pierfrancesco, Blanc, Pierluigi, Fabbiani, Massimiliano, Rossetti, Barbara, Gagliardini, Roberta, Kaiser, Rolf, Ciccozzi, Massimo, Zazzi, Maurizio
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
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Major Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511743/
https://ncbi.nlm.nih.gov/pubmed/26213689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofv043
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