Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort

Choline is an essential nutrient, and the amount needed in the diet is modulated by several factors. Given geographical differences in dietary choline intake and disparate frequencies of single-nucleotide polymorphisms (SNPs) in choline metabolism genes between ethnic groups, we tested the hypothesi...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Silver, Matt J., Corbin, Karen D., Hellenthal, Garrett, da Costa, Kerry-Ann, Dominguez-Salas, Paula, Moore, Sophie E., Owen, Jennifer, Prentice, Andrew M., Hennig, Branwen J., Zeisel, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2015
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511208/
https://ncbi.nlm.nih.gov/pubmed/25921832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-271056
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