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A new model of Pde4d deficiency: Genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without cognitive effects
Phosphodiesterases (PDEs) are a superfamily of intracellular second messenger cyclic nucleotide hydrolyzing enzymes composed of 12 families. The Pde4 family has been implicated in depression and cognition and PDE4 inhibitors have been evaluated as antidepressants and possible cognitive enhancers. Pd...
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| Publicado no: | Genes Brain Behav |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4511101/ https://ncbi.nlm.nih.gov/pubmed/22487514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1601-183X.2012.00796.x |
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