Impact of the expression of thymidylate synthase and dihydropyrimidine dehydrogenase genes on survival in stage II/III gastric cancer

BACKGROUND: The efficacy of 5-fluorouracil (5FU)-based therapy, which remains the cornerstone of gastrointestinal cancer treatment, depends upon the expression of enzymes involved in pyrimidine metabolism, including thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphor...

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Detalhes bibliográficos
Publicado no:Gastric Cancer
Main Authors: Sasako, Mitsuru, Terashima, Masanori, Ichikawa, Wataru, Ochiai, Atsushi, Kitada, Koji, Kurahashi, Issei, Sakuramoto, Shinichi, Katai, Hitoshi, Sano, Takeshi, Imamura, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Japan 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4511074/
https://ncbi.nlm.nih.gov/pubmed/25112781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10120-014-0413-8
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