Oxidative damage and mitochondrial decay in aging.
We argue for the critical role of oxidative damage in causing the mitochondrial dysfunction of aging. Oxidants generated by mitochondria appear to be the major source of the oxidative lesions that accumulate with age. Several mitochondrial functions decline with age. The contributing factors include...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1994
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45108/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7971961/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.23.10771 |
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