The 19-bp deletion polymorphism of dihydrofolate reductase (DHFR) and nonsyndromic cleft lip with or without cleft palate: evidence for a protective role

OBJECTIVE: Nonsyndromic cleft lip with or without cleft palate (NS-CL/P) are among the most common congenital birth defects worldwide. Several lines of evidence point to the involvement of folate, as well as folate metabolizing enzymes in risk reduction of orofacial clefts. Dihydrofolate reductase (...

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Vydáno v:J Appl Oral Sci
Hlavní autoři: RAFIGHDOOST, Firoozeh, RAFIGHDOOST, Amir, RAFIGHDOOST, Houshang, RIGI-LADEZ, Mohammad-Ayoob, HASHEMI, Mohammad, ESKANDARI-NASAB, Ebrahim
Médium: Artigo
Jazyk:Inglês
Vydáno: Faculdade de Odontologia de Bauru da Universidade de São Paulo 2015
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510661/
https://ncbi.nlm.nih.gov/pubmed/26221921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1678-775720140473
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