The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis

SWI/SNF complexes use the energy of ATP hydrolysis to remodel chromatin. In mammals they play a central role in regulating gene expression during differentiation and proliferation. Mutations in SWI/SNF subunits are among the most frequent gene alterations in cancer. The INI1/hSNF5/SMARCB1 subunit is...

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Bibliographic Details
Published in:Structure
Main Authors: Allen, Mark D., Freund, Stefan M.V., Zinzalla, Giovanna, Bycroft, Mark
Format: Artigo
Language:Inglês
Published: Cell Press 2015
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Short Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509781/
https://ncbi.nlm.nih.gov/pubmed/26073604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.04.021
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