Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity.
The low-affinity nerve growth factor receptor (NGFR) p75NGFR induces apoptosis in the absence of nerve growth factor (NGF) binding but enhances neural survival when bound by NGF. Basal forebrain cholinergic neurons express the highest levels of p75NGFR in the adult human brain and are preferentially...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1994
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45090/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7938014/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.22.10703 |
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