MRC-5 fibroblast-conditioned medium influences multiple pathways regulating invasion, migration, proliferation, and apoptosis in hepatocellular carcinoma

BACKGROUND: Carcinoma associated fibroblasts (CAFs), an important component of tumor microenvironment, are capable of enhancing tumor cells invasion and migration through initiation of epithelial–mesenchymal transition (EMT). MRC-5 fibroblasts are one of the CAFs expressing alpha-smooth muscle actin...

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Veröffentlicht in:J Transl Med
Hauptverfasser: Ding, Songming, Chen, Guoliang, Zhang, Wu, Xing, Chunyang, Xu, Xiao, Xie, Haiyang, Lu, Aili, Chen, Kangjie, Guo, Haijun, Ren, Zhigang, Zheng, Shusen, Zhou, Lin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508812/
https://ncbi.nlm.nih.gov/pubmed/26198300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0588-8
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