Transient Receptor Potential Channel 1 Deficiency Impairs Host Defense and Proinflammatory Responses to Bacterial Infection by Regulating Protein Kinase Cα Signaling

Transient receptor potential channel 1 (TRPC1) is a nonselective cation channel that is required for Ca(2+) homeostasis necessary for cellular functions. However, whether TRPC1 is involved in infectious disease remains unknown. Here, we report a novel function for TRPC1 in host defense against Gram-...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Zhou, Xikun, Ye, Yan, Sun, Yuyang, Li, Xuefeng, Wang, Wenxue, Privratsky, Breanna, Tan, Shirui, Zhou, Zongguang, Huang, Canhua, Wei, Yu-Quan, Birnbaumer, Lutz, Singh, Brij B., Wu, Min
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4508326/
https://ncbi.nlm.nih.gov/pubmed/26031335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00256-15
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