Synergistic antitumor effect of adenovirus armed with Drosophila melanogaster deoxyribonucleoside kinase and nucleoside analogs for human breast carcinoma in vitro and in vivo

BACKGROUND: Suicide gene therapy in cancer can selectively kill tumors without damaging normal tissues. Drosophila melanogaster multisubstrate deoxyribonucleoside kinase (Dm-dNK), an original suicide kinase, makes use of the carcinomatous suicide gene therapy for broader substrate specificity and a...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Tang, Miao, Zu, Cong, He, Anning, Wang, Wenqian, Chen, Bo, Zheng, Xinyu
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507493/
https://ncbi.nlm.nih.gov/pubmed/26203222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S81717
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