Neural activity and CaMKII protect mitochondria from fragmentation in aging Caenorhabditis elegans neurons

Decline in mitochondrial morphology and function is a hallmark of neuronal aging. Here we report that progressive mitochondrial fragmentation is a common manifestation of aging Caenorhabditis elegans neurons and body wall muscles. We show that sensory-evoked activity was essential for maintaining ne...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jiang, Hao-Ching, Hsu, Jiun-Min, Yen, Chien-Ping, Chao, Chi-Chao, Chen, Ruey-Hwa, Pan, Chun-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507213/
https://ncbi.nlm.nih.gov/pubmed/26124107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1501831112
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