Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

Our understanding of the key phosphorylation-dependent signalling pathways in the human malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue for the essential cGMP-dependent protein kinase, PfPKG. By employing chemical and genetic tools in combination with quantit...

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Pubblicato in:Nat Commun
Autori principali: Alam, Mahmood M., Solyakov, Lev, Bottrill, Andrew R., Flueck, Christian, Siddiqui, Faiza A., Singh, Shailja, Mistry, Sharad, Viskaduraki, Maria, Lee, Kate, Hopp, Christine S., Chitnis, Chetan E., Doerig, Christian, Moon, Robert W., Green, Judith L., Holder, Anthony A., Baker, David A., Tobin, Andrew B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507021/
https://ncbi.nlm.nih.gov/pubmed/26149123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8285
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