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Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.

The gene encoding Bruton tyrosine kinase (Btk) is known to be mutated in human X chromosome-linked agammaglobulinemia and in the Xid mouse. This kinase was examined in B lymphocytes before and after antigen receptor ligation and also in pre-B cells. Btk was found to be catalytically activated and ty...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Aoki, Y, Isselbacher, K J, Pillai, S
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45070/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7524098/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.22.10606
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