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Chronic NF-κB activation in CD4+ T cells in rheumatoid arthritis is genetically determined by HLA risk alleles

Of identified genetic variants, HLA polymorphisms confer the greatest risk for developing autoimmune diseases, including rheumatoid arthritis (HLA-DRB1*04). There are strong influences of HLA polymorphisms on cell-type specific gene expression in B cells and monocytes. Their influence on gene expres...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Spurlock, Charles F., Tossberg, John T., Olsen, Nancy J., Aune, Thomas M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506868/
https://ncbi.nlm.nih.gov/pubmed/26091715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500267
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