EXCESSIVE LEUKOTRIENE B4 IN NUCLEUS TRACTUS SOLITARII IS PROHYPERTENSIVE IN SPONTANEOUSLY HYPERTENSIVE RATS

Inflammation within the brainstem microvasculature has been associated with chronic cardiovascular diseases. We found that the expression of several enzymes involved in arachidonic acid (AA) - leukotriene B4 (LTB4) production was altered in NTS of SHR. LTB4 produced from AA by 5-lipoxygenase (5LOX)...

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Publicado en:Hypertension
Main Authors: Waki, Hidefumi, Hendy, Emma B., Hindmarch, Charles C.T., Gouraud, Sabine, Toward, Marie, Kasparov, Sergey, Murphy, David, Paton, Julian F.R.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506640/
https://ncbi.nlm.nih.gov/pubmed/23172924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.192252
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