Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study

Graves' disease is the leading cause of hyperthyroidism affecting 1.0–1.6% of the population. Antithyroid drugs are the treatment cornerstone, but may cause life-threatening agranulocytosis. Here we conduct a two-stage association study on two separate subject sets (in total 42 agranulocytosis...

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Publicado no:Nat Commun
Main Authors: Chen, Pei-Lung, Shih, Shyang-Rong, Wang, Pei-Wen, Lin, Ying-Chao, Chu, Chen-Chung, Lin, Jung-Hsin, Chen, Szu-Chi, Chang, Ching-Chung, Huang, Tien-Shang, Tsai, Keh Sung, Tseng, Fen-Yu, Wang, Chih-Yuan, Lu, Jin-Ying, Chiu, Wei-Yih, Chang, Chien-Ching, Chen, Yu-Hsuan, Chen, Yuan-Tsong, Fann, Cathy Shen-Jang, Yang, Wei-Shiung, Chang, Tien-Chun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506516/
https://ncbi.nlm.nih.gov/pubmed/26151496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8633
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