Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance

Adiponectin plays a key role in the regulation of the whole-body energy homeostasis by modulating glucose and lipid metabolism. Although obesity-induced reduction of adiponectin expression is primarily ascribed to a transcriptional regulation failure, the underlying mechanisms are largely undefined....

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Pubblicato in:Nat Commun
Autori principali: Kim, A. Young, Park, Yoon Jeong, Pan, Xuebo, Shin, Kyung Cheul, Kwak, Soo-Heon, Bassas, Abdulelah F., Sallam, Reem M., Park, Kyong Soo, Alfadda, Assim A., Xu, Aimin, Kim, Jae Bum
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506505/
https://ncbi.nlm.nih.gov/pubmed/26139044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8585
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