6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that suppress effector T cell responses and can reduce the efficacy of cancer immunotherapies. We previously showed that ultra-small polymer nanoparticles efficiently drain to the lymphatics after intra...

Full description

Saved in:
Bibliographic Details
Published in:Cancer Immunol Immunother
Main Authors: Jeanbart, Laura, Kourtis, Iraklis C., van der Vlies, André J., Swartz, Melody A., Hubbell, Jeffrey A.
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2015
Subjects:
Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506469/
https://ncbi.nlm.nih.gov/pubmed/25982370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-015-1702-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items