A phase II and pharmacodynamic study of sunitinib in relapsed/refractory oesophageal and gastro-oesophageal cancers

BACKGROUND: Blockade of the vascular endothelial growth factor (VEGF) pathway shows evidence of activity in gastro-oesophageal (GE) and oesophageal cancer. We investigated the efficacy of sunitinib, a multikinase VEGF inhibitor, in patients with relapsed/refractory GE/oesophageal cancer. METHODS: Th...

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Vydáno v:Br J Cancer
Hlavní autoři: Wu, C, Mikhail, S, Wei, L, Timmers, C, Tahiri, S, Neal, A, Walker, J, El-Dika, S, Blazer, M, Rock, J, Clark, D J, Yang, X, Chen, J L, Liu, J, Knopp, M V, Bekaii-Saab, T
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
Clinical Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506385/
https://ncbi.nlm.nih.gov/pubmed/26151457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.197
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