Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethane

As part of the international Pig-a validation trials, we examined the induction of Pig-a mutant reticulocytes and red blood cells (RET(CD59−) and RBC(CD59−), respectively) in peripheral blood of male Sprague Dawley(®) rats treated with urethane (25, 100 and 250mg/kg/day) or saline by oral gavage for...

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Detalhes bibliográficos
Publicado no:Mutagenesis
Main Authors: Stankowski, Leon F., Aardema, Marilyn J., Lawlor, Timothy E., Pant, Kamala, Roy, Shambhu, Xu, Yong, Elbekai, Reem
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Special Topic: Pig-a Mutation Assay
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506322/
https://ncbi.nlm.nih.gov/pubmed/25934985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/gev013
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