Silencing nociceptor neurons reduces allergic airway inflammation

Lung nociceptors initiate cough and bronchoconstriction. To elucidate if these fibers also contribute to allergic airway inflammation we stimulated lung nociceptors with capsaicin and observed increased neuropeptide release and immune cell infiltration. In contrast, ablating Nav1.8(+) sensory neuron...

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Publicado en:Neuron
Autores principales: Talbot, Sébastien, Abdulnour, Raja-Elie E., Burkett, Patrick R., Lee, Seungkyu, Cronin, Shane J.F., Pascal, Maud A., Laedermann, Cedric, Foster, Simmie L., Tran, Johnathan V., Lai, Nicole, Chiu, Isaac M., Ghasemlou, Nader, DiBiase, Matthew, Roberson, David, Von Hehn, Christian, Agac, Busranour, Haworth, Oliver, Seki, Hiroyuki, Penninger, Josef M., Kuchroo, Vijay K., Bean, Bruce P., Levy, Bruce D., Woolf, Clifford J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506220/
https://ncbi.nlm.nih.gov/pubmed/26119026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.06.007
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