Silencing nociceptor neurons reduces allergic airway inflammation

Lung nociceptors initiate cough and bronchoconstriction. To elucidate if these fibers also contribute to allergic airway inflammation we stimulated lung nociceptors with capsaicin and observed increased neuropeptide release and immune cell infiltration. In contrast, ablating Nav1.8(+) sensory neuron...

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Publicado no:Neuron
Main Authors: Talbot, Sébastien, Abdulnour, Raja-Elie E., Burkett, Patrick R., Lee, Seungkyu, Cronin, Shane J.F., Pascal, Maud A., Laedermann, Cedric, Foster, Simmie L., Tran, Johnathan V., Lai, Nicole, Chiu, Isaac M., Ghasemlou, Nader, DiBiase, Matthew, Roberson, David, Von Hehn, Christian, Agac, Busranour, Haworth, Oliver, Seki, Hiroyuki, Penninger, Josef M., Kuchroo, Vijay K., Bean, Bruce P., Levy, Bruce D., Woolf, Clifford J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506220/
https://ncbi.nlm.nih.gov/pubmed/26119026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.06.007
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