High-Throughput Analysis of Human Cytomegalovirus Genome Diversity Highlights the Widespread Occurrence of Gene-Disrupting Mutations and Pervasive Recombination

Human cytomegalovirus is a widespread pathogen of major medical importance. It causes significant morbidity and mortality in immunocompromised individuals, and congenital infections can result in severe disabilities or stillbirth. Development of a vaccine is prioritized, but no candidate is close to...

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Vydáno v:J Virol
Hlavní autoři: Sijmons, Steven, Thys, Kim, Mbong Ngwese, Mirabeau, Van Damme, Ellen, Dvorak, Jan, Van Loock, Marnix, Li, Guangdi, Tachezy, Ruth, Busson, Laurent, Aerssens, Jeroen, Van Ranst, Marc, Maes, Piet
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Genetic Diversity and Evolution
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505652/
https://ncbi.nlm.nih.gov/pubmed/25972543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00578-15
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