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Interferon Beta and Interferon Alpha 2a Differentially Protect Head and Neck Cancer Cells from Vesicular Stomatitis Virus-Induced Oncolysis

Oncolytic viruses (OV) preferentially kill cancer cells due in part to defects in their antiviral responses upon exposure to type I interferons (IFNs). However, IFN responsiveness of some tumor cells confers resistance to OV treatment. The human type I IFNs include one IFN-β and multiple IFN-α subty...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Westcott, Marlena M., Liu, Jingfang, Rajani, Karishma, D'Agostino, Ralph, Lyles, Douglas S., Porosnicu, Mercedes
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505650/
https://ncbi.nlm.nih.gov/pubmed/25995245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00757-15
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