A Salt Bridge Linking the First Intracellular Loop with the C Terminus Facilitates the Folding of the Serotonin Transporter

The folding trajectory of solute carrier 6 (SLC6) family members is of interest because point mutations result in misfolding and thus cause clinically relevant phenotypes in people. Here we examined the contribution of the C terminus in supporting folding of the serotonin transporter (SERT; SLC6A4)....

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Koban, Florian, El-Kasaby, Ali, Häusler, Cornelia, Stockner, Thomas, Simbrunner, Benedikt M., Sitte, Harald H., Freissmuth, Michael, Sucic, Sonja
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505579/
https://ncbi.nlm.nih.gov/pubmed/25869136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.641357
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