Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis

The maturation and maintenance of dendritic spines depends on neuronal activity and protein synthesis. One potential mechanism involves mammalian target of rapamycin, which promotes protein synthesis through phosphorylation of eIF4E-binding protein and p70 ribosomal S6 kinase 1 (S6K). Upon extracell...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lai, Kwok-On, Liang, Zhuoyi, Fei, Erkang, Huang, Huiqian, Ip, Nancy Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505530/
https://ncbi.nlm.nih.gov/pubmed/25903132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627117
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