A Novel Peroxisome Proliferator-activated Receptor (PPAR)α Agonist and PPARγ Antagonist, Z-551, Ameliorates High-fat Diet-induced Obesity and Metabolic Disorders in Mice

A novel peroxisome proliferator-activated receptor (PPAR) modulator, Z-551, having both PPARα agonistic and PPARγ antagonistic activities, has been developed for the treatment of obesity and obesity-related metabolic disorders. We examined the effects of Z-551 on obesity and the metabolic disorders...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Shiomi, Yoshihiro, Yamauchi, Toshimasa, Iwabu, Masato, Okada-Iwabu, Miki, Nakayama, Ryo, Orikawa, Yuki, Yoshioka, Yoshichika, Tanaka, Koichiro, Ueki, Kohjiro, Kadowaki, Takashi
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Metabolism
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505524/
https://ncbi.nlm.nih.gov/pubmed/25907553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.622191
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