Association of MMP7 −181A→G Promoter Polymorphism with Gastric Cancer Risk: INFLUENCE OF NICOTINE IN DIFFERENTIAL ALLELE-SPECIFIC TRANSCRIPTION VIA INCREASED PHOSPHORYLATION OF cAMP-RESPONSE ELEMENT-BINDING PROTEIN (CREB)

Elevated expression of matrix metalloproteinase7 (MMP7) has been demonstrated to play a pivotal role in cancer invasion. The −181A→G (rs11568818) polymorphism in the MMP7 promoter modulates gene expression and possibly affects cancer progression. Here, we evaluated the impact of −181A→G polymorphism...

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Vydáno v:J Biol Chem
Hlavní autoři: Kesh, Kousik, Subramanian, Lakshmi, Ghosh, Nillu, Gupta, Vinayak, Gupta, Arnab, Bhattacharya, Samir, Mahapatra, Nitish R., Swarnakar, Snehasikta
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505507/
https://ncbi.nlm.nih.gov/pubmed/25847246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.630129
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