MAD1L1 Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer

The spindle assembly checkpoint (SAC) has been established as an important mechanism of driving aneuploidy, which occurs at a high frequency in the colorectal tumorigenesis. Two important components of SAC are MAD1L1 and MAD2L1, which function together in an interactive manner to initiate the checkp...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Zhong, Rong, Chen, Xiaohua, Chen, Xueqin, Zhu, Beibei, Lou, Jiao, Li, Jiaoyuan, Shen, Na, Yang, Yang, Gong, Yajie, Zhu, Ying, Yuan, Jing, Xia, Xiaoping, Miao, Xiaoping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505328/
https://ncbi.nlm.nih.gov/pubmed/26183163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12202
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