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Premature aging of the hippocampal neurogenic niche in adult Bmal1‐ deficient mice
Hippocampal neurogenesis undergoes dramatic age‐related changes. Mice with targeted deletion of the clock gene Bmal1 (Bmal1(‐/‐)) show disrupted regulation of reactive oxygen species homeostasis, accelerated aging, neurodegeneration and cognitive deficits. As proliferation of neuronal progenitor/pre...
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| Veröffentlicht in: | Aging (Albany NY) |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Impact Journals LLC
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4505169/ https://ncbi.nlm.nih.gov/pubmed/26142744 |
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