Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCF(FBXL2) E3 Ligase

The inflammasome is a multiprotein complex that augments the proinflammatory response by increasing the generation and cellular release of key cytokines. Specifically, the NALP3 inflammasome requires two-step signaling, priming and activation, to be functional to release the proinflammatory cytokine...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Han, SeungHye, Lear, Travis B., Jerome, Jacob A., Rajbhandari, Shristi, Snavely, Courtney A., Gulick, Dexter L., Gibson, Kevin F., Zou, Chunbin, Chen, Bill B., Mallampalli, Rama K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505057/
https://ncbi.nlm.nih.gov/pubmed/26037928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.645549
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