Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation

Albuminuria contributes to the development and progression of chronic kidney disease by inducing tubulointerstitial inflammation (TI) and fibrosis. However, the exact mechanisms of TI in response to albuminuria are unresolved. We previously demonstrated that NLRP3 and inflammasomes mediate albumin-i...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Liu, Dan, Wen, Yi, Tang, Tao-Tao, Lv, Lin-Li, Tang, Ri-Ning, Liu, Hong, Ma, Kun-Ling, Crowley, Steve D., Liu, Bi-Cheng
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505048/
https://ncbi.nlm.nih.gov/pubmed/26025362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662064
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