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Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation

Albuminuria contributes to the development and progression of chronic kidney disease by inducing tubulointerstitial inflammation (TI) and fibrosis. However, the exact mechanisms of TI in response to albuminuria are unresolved. We previously demonstrated that NLRP3 and inflammasomes mediate albumin-i...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Liu, Dan, Wen, Yi, Tang, Tao-Tao, Lv, Lin-Li, Tang, Ri-Ning, Liu, Hong, Ma, Kun-Ling, Crowley, Steve D., Liu, Bi-Cheng
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505048/
https://ncbi.nlm.nih.gov/pubmed/26025362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.662064
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