Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches

OBJECTIVE: The ductular reaction (DR) involves mobilisation of reactive-appearing duct-like cells (RDC) along canals of Hering, and myofibroblastic (MF) differentiation of hepatic stellate cells (HSC) in the space of Disse. Perivascular cells in stem cell niches produce pleiotrophin (PTN) to inactiv...

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Bibliografische gegevens
Gepubliceerd in:Gut
Hoofdauteurs: Michelotti, Gregory A, Tucker, Anikia, Swiderska-Syn, Marzena, Machado, Mariana Verdelho, Choi, Steve S, Kruger, Leandi, Soderblom, Erik, Thompson, J Will, Mayer-Salman, Meredith, Himburg, Heather A, Moylan, Cynthia A, Guy, Cynthia D, Garman, Katherine S, Premont, Richard T, Chute, John P, Diehl, Anna Mae
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMJ Publishing Group 2016
Onderwerpen:
Hepatology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504836/
https://ncbi.nlm.nih.gov/pubmed/25596181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-308176
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