Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches

OBJECTIVE: The ductular reaction (DR) involves mobilisation of reactive-appearing duct-like cells (RDC) along canals of Hering, and myofibroblastic (MF) differentiation of hepatic stellate cells (HSC) in the space of Disse. Perivascular cells in stem cell niches produce pleiotrophin (PTN) to inactiv...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Michelotti, Gregory A, Tucker, Anikia, Swiderska-Syn, Marzena, Machado, Mariana Verdelho, Choi, Steve S, Kruger, Leandi, Soderblom, Erik, Thompson, J Will, Mayer-Salman, Meredith, Himburg, Heather A, Moylan, Cynthia A, Guy, Cynthia D, Garman, Katherine S, Premont, Richard T, Chute, John P, Diehl, Anna Mae
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2016
Assuntos:
Hepatology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504836/
https://ncbi.nlm.nih.gov/pubmed/25596181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-308176
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