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Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

Lactate has long been considered a “waste” by-product of cell metabolism, and it accumulates at sites of inflammation. Recent findings have identified lactate as an active metabolite in cell signalling, although its effects on immune cells during inflammation are largely unexplored. Here we ask whet...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Haas, Robert, Smith, Joanne, Rocher-Ros, Vidalba, Nadkarni, Suchita, Montero-Melendez, Trinidad, D’Acquisto, Fulvio, Bland, Elliot J., Bombardieri, Michele, Pitzalis, Costantino, Perretti, Mauro, Marelli-Berg, Federica M., Mauro, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504715/
https://ncbi.nlm.nih.gov/pubmed/26181372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1002202
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