Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model

BACKGROUND: In clinic settings, rel apsed leukemic patients are found to be more fragile to chemotherapy due to delayed or incomplete hematopoietic recovery, and hematopoiesis of these patients seem to be impaired. METHODS: We established a leukemia therapy model with a non-irradiated T cell acute l...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Jiang, Chuanhe, Hu, Xiaoxia, Wang, Libing, Cheng, Hui, Lin, Yan, Pang, Yakun, Yuan, Weiping, Cheng, Tao, Wang, Jianmin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504405/
https://ncbi.nlm.nih.gov/pubmed/26183432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0543-8
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