Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes

Taxanes are widely employed chemotherapies for patients with metastatic prostate and breast cancer. Here, we show that loss of Diaphanous-related formin-3 (DIAPH3), frequently associated with metastatic breast and prostate cancers, correlates with increased sensitivity to taxanes. DIAPH3 interacted...

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Vydáno v:Sci Rep
Hlavní autoři: Morley, Samantha, You, Sungyong, Pollan, Sara, Choi, Jiyoung, Zhou, Bo, Hager, Martin H., Steadman, Kenneth, Spinelli, Cristiana, Rajendran, Kavitha, Gertych, Arkadiusz, Kim, Jayoung, Adam, Rosalyn M., Yang, Wei, Krishnan, Ramaswamy, Knudsen, Beatrice S., Di Vizio, Dolores, Freeman, Michael R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503992/
https://ncbi.nlm.nih.gov/pubmed/26179371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12136
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