Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes

Taxanes are widely employed chemotherapies for patients with metastatic prostate and breast cancer. Here, we show that loss of Diaphanous-related formin-3 (DIAPH3), frequently associated with metastatic breast and prostate cancers, correlates with increased sensitivity to taxanes. DIAPH3 interacted...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Morley, Samantha, You, Sungyong, Pollan, Sara, Choi, Jiyoung, Zhou, Bo, Hager, Martin H., Steadman, Kenneth, Spinelli, Cristiana, Rajendran, Kavitha, Gertych, Arkadiusz, Kim, Jayoung, Adam, Rosalyn M., Yang, Wei, Krishnan, Ramaswamy, Knudsen, Beatrice S., Di Vizio, Dolores, Freeman, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503992/
https://ncbi.nlm.nih.gov/pubmed/26179371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12136
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