Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS

Dimethyl fumarate (DMF), recently approved as an oral immunomodulatory treatment for relapsing-remitting multiple sclerosis (MS), metabolizes to monomethyl fumarate (MMF) which crosses the blood–brain barrier and has demonstrated neuroprotective effects in experimental studies. We postulated that MM...

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Veröffentlicht in:Acta Neuropathol
Hauptverfasser: Parodi, Benedetta, Rossi, Silvia, Morando, Sara, Cordano, Christian, Bragoni, Alberto, Motta, Caterina, Usai, Cesare, Wipke, Brian T., Scannevin, Robert H., Mancardi, Giovanni L., Centonze, Diego, Kerlero de Rosbo, Nicole, Uccelli, Antonio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2015
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503882/
https://ncbi.nlm.nih.gov/pubmed/25920452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1422-3
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